Tagged: tumor

Exercise and the Hallmarks of Cancer

A wealth of evidence supports an association between regular physical activity (PA) and decreased risk for cancer and cancer mortality. This is clearly an important issue given the growing worldwide incidence of both cancer...

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Tracking the Evolution of Non–Small-Cell Lung Cancer

BACKGROUNDAmong patients with non–small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to clinical outcome...

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A new cancer ecosystem

Cancer is increasingly being viewed as an ecosystem, a community in which tumor cells cooperate with other tumor cells and host cells in their microenvironment. As conditions change, the ecosystem evolves and adapts to...

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Exploiting cancer metabolism

Cancer-specific cell surface proteins can be targeted for the delivery of therapeutic agents. However, specific proteins may not always be expressed by a tumor. Wang et al. overcome this challenge by designing sugars to...

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George Klein (1925–2016)

George Klein, with his wife, Eva, discovered foundational phenomena in cancer research. He showed that normal cells carry genes, now known as tumour suppressors, that prevent cancer. He also worked out how the immune...

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Fragment Length of Circulating Tumor DNA

Abstract Malignant tumors shed DNA into the circulation. The transient half-life of circulating tumor DNA (ctDNA) may afford the opportunity to diagnose, monitor recurrence, and evaluate response to therapy solely through a non-invasive blood...

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Facilitating Tumor Cell Migration

Emerging evidence suggests that metastasis the spread of cancer from one organ or tissue to another—is aided by a significant remodeling of the cancer cells’ surroundings. Now, researchers at MIT have made progress toward...

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Blocking tumor cell transitions

A process called the epithelial-to-mesenchymal transition allows cancer cells to invade nearby tissue and metastasize. Katz et al.investigated the molecular underpinnings of this process and determined that tumors with a more epithelial gene signature...

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Signaling Resistance

EDITOR’S CHOICE IN CELL & MOLECULAR BIOLOGY The paper C.A. Martz et al., “Systematic identification of signaling pathways with potential to confer anticancer drug resistance,” Science Signaling, 7:ra121, 2014. The debate Researchers have two...

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