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Sickle Cell Disease

Sickle cell disease is caused by an alteration in a single DNA base, but its clinical manifestations are influenced by other genes and behavioral and environmental factors. Recent findings may indicate an acceleration in...

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A new cancer ecosystem

Cancer is increasingly being viewed as an ecosystem, a community in which tumor cells cooperate with other tumor cells and host cells in their microenvironment. As conditions change, the ecosystem evolves and adapts to...

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Brain cancer therapy

Glioblastoma multiforme (GBM) is a deadly brain cancer, and a major challenge to its treatment with radiation is that the approach often leads to an even more aggressive form of the cancer. Kegelman et...

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Initiating an antitumor attack

Cancer is notorious for relapsing after treatment. Such relapses are driven by tumor-initiating cells, a type of stem cell that gives rise to tumors. Damelin et al. determined that a protein called PTK7 is...

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A new direction for breast cancer therapy

Triple-negative breast cancer has the worst prognosis of the breast cancer subtypes. Aggressive forms of this cancer show elevated signaling through the transcription factor MYC, but blocking MYC activity remains challenging because of its...

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Control ALT, Delete Cancer

Because age is the largest risk factor for cancer, as the life expectancy of the world’s population continues to increase, cancer incidence is projected to rise dramatically. A 2011 report on Global Health and...

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