Tagged: T cells

CHILD ARCHIVE CHILD ARCHIVE
CHILD ARCHIVE

Cardiac side effect

Antibodies that block CTLA-4 (cytotoxic T lymphocyte–associated antigen 4) and PD-1 (programmed death 1) allow T cells to launch antitumor immune responses. Although these checkpoint inhibitors improve survival in melanoma patients, inflammation of other...

CHILD ARCHIVE
CHILD ARCHIVE

CRISPR Therapy to Enter Trials

Oncologist You Lu of Sichuan University’s West China Hospital in Chengdu and colleagues will soon begin trialing a new CRISPR-based immunotherapy in 10 patients with non-small cell lung cancer that has metastasized and is...

CHILD ARCHIVE

Long-Lived Immune Memories

Following genetically marked donor memory T cells infused into hematopoietic stem cell transplantation patients, a team led by researchers at the University Vita-Salute San Raffaele in Milan, Italy, found that two types of less-differentiated...

CHILD ARCHIVE CHILD ARCHIVE

How T cells maintain their identity

Although best known for their pathogen-fighting prowess, T lymphocytes also ensure that the immune response does not run amok. A subset of T cells called regulatory T cells (Tregs) performs this function by, for...

CHILD ARCHIVE CHILD ARCHIVE

Cancer immunotherapy expands T cell attack

Patients with advanced melanoma can survive longer after treatment with the immunotherapy drug ipilimumab. Kvistborg et al. show how this therapeutic antibody exerts its beneficial effects. Although directed against an immune inhibitor, the drug unexpectedly failed...

CHILD ARCHIVE

Speeding Up Antiviral T Cell Production

Therapeutic transfer of virus-specific T cells to immunocompromised patients can help battle life-threatening infections, but the process for generating such cells is lengthy and laborious. A paper published today (June 25) in Science Translational Medicine, however,...

CHILD ARCHIVE