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How red berries reduce inflammation

Members of the interleukin-17 (IL-17) family of proinflammatory cytokines are important in the immune response to infections. However, too much IL-17 signaling is associated with autoimmune inflammatory diseases, such as asthma, psoriasis, and rheumatoid...

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Cardiac side effect

Antibodies that block CTLA-4 (cytotoxic T lymphocyte–associated antigen 4) and PD-1 (programmed death 1) allow T cells to launch antitumor immune responses. Although these checkpoint inhibitors improve survival in melanoma patients, inflammation of other...

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Long-Lived Immune Memories

Following genetically marked donor memory T cells infused into hematopoietic stem cell transplantation patients, a team led by researchers at the University Vita-Salute San Raffaele in Milan, Italy, found that two types of less-differentiated...

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Cancer immunotherapy expands T cell attack

Patients with advanced melanoma can survive longer after treatment with the immunotherapy drug ipilimumab. Kvistborg et al. show how this therapeutic antibody exerts its beneficial effects. Although directed against an immune inhibitor, the drug unexpectedly failed...

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Speeding Up Antiviral T Cell Production

Therapeutic transfer of virus-specific T cells to immunocompromised patients can help battle life-threatening infections, but the process for generating such cells is lengthy and laborious. A paper published today (June 25) in Science Translational Medicine, however,...

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