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The organoid architect

By her 50th birthday, Els van der Heijden felt sicker than ever. Born with the hereditary disorder cystic fibrosis (CF), she had managed to work around her illness, finishing college and landing a challenging...

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The stem cell skeptic

Paul Knoepfler is an unlikely watchdog for the therapeutic stem cell industry. His University of California, Davis, lab mostly uses stem cells to study cancer-causing gene mutations—not to develop potential therapies. But thanks to...

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Blood Stem Cells Grown in the Lab

Two teams of scientists have generated blood stem cells by reprogramming either human or mouse cells. In both cases, these hematopoietic stem cells successfully produced blood cells when implanted into mice. “This is important...

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Donor Stem Cells Improve Cardiac Function

Cardiac muscle cells derived from induced pluripotent stem cells (iPSCs) and injected into monkeys helped the animals’ hearts recover from a heart attack, according to a study published yesterday (October 10) inNature. The iPSCs...

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CRISPR Corrects Retinal Disease Mutation

Retinitis pigmentosa, an inherited disease causing progressive degeneration of the retina, is repsonsible for blindness in approximately 1.5 million people worldwide. Using patient-derived stem cells, researchers in the U.S. have now used the CRISPR/Cas9...

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Frequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during Aging

Highlights •The aging Drosophila intestine is genetically mosaic •Somatic recombination, genomic deletions, and rearrangements occur in aging ISCs •Somatic inactivation of the tumor-suppressor Notch causes male-specific neoplasia Summary Adult stem cells may acquire mutations...

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STEM CELLS AND HEALTHY AGING

Research into stem cells and aging aims to understand how stem cells maintain tissue health, what mechanisms ultimately lead to decline in stem cell function with age, and how the regenerative capacity of somatic...

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Mitochondria Swap

Scientists have used two methods to generate patient-specific pluripotent stem cells with normal mitochondria for people with defects in these organelles, according to a study published today (July 15) in Nature. The first method...

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