Tagged: obesity

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Obesity: The fat advantage

Attendees at the 2015 Genitourinary Cancers Symposium in Orlando, Florida, were presented with a head scratcher. At a poster session on renal cancer, a team at the Dana-Farber Cancer Institute in Boston, Massachusetts, led...

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Goodbye to the BMI

Researchers from University of California, Santa Barbara and UCLA report that millions of Americans labeled overweight or obese based on their body mass index (BMI) are, in fact, perfectly healthy. Their findings (“Misclassification of...

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Limiting inflammation in obesity

Obese individuals have increased circulating levels of inflammatory cytokines produced by adipose tissue macrophages. Velmurugan et al. found that adipose tissue macrophages from obese mice had decreased levels of the gasotransmitter H2S, increased calcium...

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Obesity Alters Sperm Epigenome

A team led by researchers from the University of Copenhagen discovered differences in the sperm epigenomes of lean and obese men, and in the sperm of obese men before and after bariatric surgery, according...

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Bile Benefits

For obese patients undergoing a gastric bypass, such as the commonly used Roux-en-Y procedure, the surgery is extensive. “It basically changes the whole anatomy of the GI tract,” says Naji Abumrad of Vanderbilt University....

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Fat Factors

Obesogens, such as the extensively studied fungicide tributyltin (TBT), can act in a variety of ways to promote fat storage and adipose tissue production, often by disrupting hormonal signaling. Such effects have been well...

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The 6,000-Calorie Diet

Between October 2013 and July 2014, six healthy, middle-aged men reported to Temple University Hospital in north Philadelphia. For seven days, researchers confined each subject to his hospital bed and told him to select...

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Battling the Bulge

Several years ago, antiobesity drug development was not looking so hot. In 2007, Sanofi-Aventis failed to win US Food and Drug Administration (FDA) approval for rimonabant a pill that successfully helped people shed pounds...

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Warming Up to Brown Fat

Brown fat the form of adipose tissue that burns, rather than stores, energy was only recently discovered to exist in adult humans. For decades, researchers knew it was present in rodents, whose brown fat...

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How Fats Influence the Microbiome

The types of lipids mice consume affect the composition of their gut microbiota, which influences whether the animals develop obesity-related inflammation, according to a study published today (August 27) in Cell Metabolism. Mice fed...

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Drug Stimulates Brown Fat

The stimulation of so-called brown fat the energy-burning kind is thought to be a potential therapeutic target for obesity. In a study published in Cell Metabolism this month (January 6), researchers gave volunteers an already-approved...

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Obesity Gene Weightier, Depending on Year of Birth

Disentangling nature and nurture just got more complicated. Now it seems that time, too, may be involved in gene/environment interactions, say scientists who evaluated the effects of a gene variant long associated with obesity...

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Obesity-Cancer Link Detailed

Obesity spurs changes in the gut microbiome that can lead to the production of DNA-damaging metabolites. And according to new research published today (June 26) in Nature, circulation of these metabolites through the gut and...

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