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Developing an HIV vaccine

In 2015, 17 million HIV-infected individuals worldwide were on antiretroviral drug therapies, which are remarkably effective in suppressing the virus. Yet, 6000 people a day became newly infected, making the quest for an effective...

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Drugging an undruggable target

Transcription factors have long been viewed as “undruggable” targets for therapy: however, this concept may now need some tweaking. Cho et al. found that a small-molecule drug (PT2399) that inhibits the activity of the...

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