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Cliques and Schisms of Cancer Genes

With a few exceptions, cancers typically carry more than one driver mutation, sometimes five, ten, or more, and these driver mutations do not necessarily assort randomly. In this issue of Cancer Cell, Mina et...

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Cell biology: Healthy skin rejects cancer

Live imaging shows that healthy skin cells surround and expel neighbours that have cancer-promoting mutations, revealing that tissues can recognize and eliminate mutant cells to prevent tumour initiation.

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PARP Inhibitors for Cancer Therapy

Summary Rucaparib is an inhibitor of nuclear poly (ADP-ribose) polymerases (inhibition of PARP-1 > PARP-2 > PARP-3), following a similar drug, Olaparib. It disrupts DNA repair and replication pathways (and possibly transcription), leading to...

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Mosaic mutations in autism

Spontaneously arising de novo mutations are likely important contributors to the development of autism spectrum disorder (ASD) in affected individuals. Genetic mutation is an ongoing process. Although people inherit deleterious mutations from their parents,...

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Jewish Heritage Written in DNA

Whole-genome sequences from 128 healthy Jewish people could help the medical community identify disease-associated variants in those of Ashkenazi ancestry, according to a study published today (September 9) in Nature Communications. The library of sequences...

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Mosaic Mutations

When a couple has a child with a genetic disorder, they often ask how likely they are to pass the disorder on to another child. To determine the risk of this happening, clinicians must...

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New Genetic Mutation Linked to Parkinson’s Disease was discovered using the “exome” new genetic sequencing technique

The American Journal of Human Genetics, Volume 89, Issue 1, p162, 15 July 2011. Carles Vilariño-Güell, Christian Wider, Owen A. Ross, Justus C. Dachsel et al. “VPS35 Mutations in Parkinson Disease. Researchers have discovered...

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