Tagged: microbiology

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Toward Killing Cancer with Bacteria

A genetically manipulated version of the gastroenteritis-causing bacteria Salmonella typhimurium is a potent destroyer of mouse tumors, according to a report published today (February 8) in Science Translational Medicine. The paper adds to a...

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New CRISPR-Cas Enzymes Discovered

Microbes use a number of CRISPR-Cas systems for immunity, but it’s the class 2 system, typically utilizing the nuclease Cas9, that has been adapted for genome editing. A metagenomics search of microbes sampled from...

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Phages Carry Antibiotic Resistance Genes

Viromes from a variety of environments harbor antibiotic resistance genes, according to a study published last month (November 24) in Environmental Pollution. The results suggest that bacteriophages—viruses that infect bacteria—may play a role in...

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Viruses of the Human Body

S ince the dawn of microbiology, researchers have focused on pathogens that make us and our domesticated animals and plants sick. Because the onset of symptoms was the only way to know if specific...

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Fecal Transplant Pill Fails Trial

Earlier this year, Seres Therapeutics publishedpromising data from an early-stage trial for its SER-109, a pill containing bacterial spores isolated from stool samples for patients with recurring Clostridium difficile infections (CDIs). The therapy seemed to be...

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Spoiler Alert

n the last decade or so, researchers have spent billions of dollars categorizing the microbes that populate sites as disparate as the human body, soil, and the oceans. Much of what we know about...

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Metformin Users Have Different Gut Bugs

Diabetics who use the commonly prescribed drug metformin to control blood sugar levels have a different composition of gut microbiota than other diabetics, according to a study published in Naturelast week (December 2). The...

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Blood-Gut Barrier

A person’s gut is full of microbes some beneficial, some not. Friend or foe, these bacteria must be prevented from accessing the rest of the body, where they could cause harm. In a paper...

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Skin Microbes Help Clear Infection

To understand whether the human skin microbiome can affect the ability of a bacterial pathogen to cause an infection, researchers have had to rely on observational studies. Now, taking advantage of a unique human skin...

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The Search for Persisters

It starts with a tick bite. This may be followed by the characteristic bullseye rash. And then the other symptoms of Lyme disease appear. Fever, fatigue, body aches, and headaches can all set in....

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Toward Yeast–Based Opioid Production.

In 2008, a team led by Stanford University’sChristina Smolke, then at Caltech, showed in Nature Chemical Biology that engineered yeast (Saccharomyces cerevisiae) could produce benzylisoquinoline alkaloid (BIA) metabolites, including the alkaloids from which morphine is derived....

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Ulcer-forming Bacteria Target Tiny Traumas

The ulcer-causing bacteria Helicobacter pyloriswiftly swarm to sites of microscopic damage on the surface of the mouse stomach. The microbes accumulate at these injury sites within minutes, and can slow tissue repair. These are the...

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