Tagged: infectious disease

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Pathway to Polio Virulence Revealed

Polio is nearly eradicated. Now much of the risk of polio outbreaks comes not from wild poliovirus but from the oral vaccine, which comprises attenuated viruses. These viruses accumulate mutations that allow them to...

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Zika Infects Adult Neural Progenitors Too

Zika virus exposure in a mouse model can infect adult neural stem cells in the brain, leading to cell death and reduced proliferation.CELL STEM CELL, H. LI ET AL.Microcephaly and associated birth defects in...

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Zika Up Close

As concerns over the spread of Zika virus through the Americas rise, and evidence showing that the virus can infect developing neurons accumulates, a team led by researchers at Purdue University has now described the...

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Toward a Universal Flu Vax

Researchers in Australia added an adjuvant to an inactivated influenza A vaccine and successfully boosted the shot’s effectiveness and cross-protective capabilities, according to a study published today (October 27) in mBio. “Our best protection comes...

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Rapid Ebola Test Approved

A few drops of blood are all that’s needed to test for Ebola using a newly approved paper-based diagnostic test. Approved by the World Health Organization(WHO) last week (February 20), the ReEBOV Antigen Rapid...

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Top Science Scandals of 2014

As always, in addition to the scientific breakthroughs that make headlines throughout the year, there is also a dark side to science. From misconduct to human error, there is always the possibility for something...

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Modeling Ebola in Mice

Researchers investigating host responses to Ebola have long faced a significant disadvantage: the virus kills conventional lab mice, but does not produce the hemorrhagic fever or other classical symptoms that occur in humans. The...

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Taking the temperature of virulence

Cholera kills more than 100,000 people yearly and results from consuming food or water contaminated with Vibrio cholerae. The bacterium only expresses virulence factors, proteins that cause disease, when it infects people. Weber et...

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Clone wars: Let’s pick out the superbugs

Since the 1960s, group B streptococci (GBS) have lost genetic diversity, yet they cause more virulent neonatal infections and show high rates of tetracycline resistance. The puzzle is that tetracycline is not used to...

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Malaria drives T cells to exhaustion.

Malaria is a significant global burden but after >30 years of effort there is no vaccine on the market. While the complex life cycle of the parasite presents several challenges, many years of research...

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How immune cells fight TB and show it

Mycobacterium tuberculosis causes an infection that can sometimes kill, but it proceeds to disease in only about 10% of individuals. Now, Montoya et al. provide a clue to how most people keep this bacterium in check. They...

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US assesses virus of the Caribbean

In the past few months, passengers at North American airports have been warned that travel to the Caribbean might result in an unwanted souvenir. The first outbreak of chikungunya virus in the Western Hemisphere...

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