Tagged: immunotherapy

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Tasmanian Devil Cancer Immunotherapy

Scientists working to slow the spread of a deadly facial cancer through populations of the Tasmania’s iconic marsupial Sarcophilus harrisii, or the Tasmanian devil, have announced progress by injecting live cancer cells into individuals...

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The double edge of cancer immunotherapy

Immunotherapies have shown unprecedented efficacy in the treatment of several cancers, including melanoma and lymphoma, and they are now in clinical trials for many others. This type of treatment can differ in form, ranging...

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Toward Killing Cancer with Bacteria

A genetically manipulated version of the gastroenteritis-causing bacteria Salmonella typhimurium is a potent destroyer of mouse tumors, according to a report published today (February 8) in Science Translational Medicine. The paper adds to a...

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Locking TNFR2 to kill ovarian cancer

The TNF (tumor necrosis factor) ligand family promotes tumor growth and progression. Torrey et al. developed an antibody that locks TNFR2, a TNF receptor found on immunosuppressive regulatory T cells and some tumor cells,...

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Cardiac side effect

Antibodies that block CTLA-4 (cytotoxic T lymphocyte–associated antigen 4) and PD-1 (programmed death 1) allow T cells to launch antitumor immune responses. Although these checkpoint inhibitors improve survival in melanoma patients, inflammation of other...

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Large Tumors Destroyed by Innate/Adaptive Immunotherapy Combo

If combination immunotherapies show promise against established tumors, why not try super-combo immunotherapies? That’s the question that occurred to MIT scientists, who had achieved partial successes with various biomolecular drugs. By combining all four...

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CRISPR Therapy to Enter Trials

Oncologist You Lu of Sichuan University’s West China Hospital in Chengdu and colleagues will soon begin trialing a new CRISPR-based immunotherapy in 10 patients with non-small cell lung cancer that has metastasized and is...

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Cancer Immunotherapy Booster

Cancer research is a rapidly evolving field with new discoveries emerging daily on its biology, prevention, diagnosis, and treatment. In particular, the recent achievement of several key immunotherapy milestones dramatically changed the landscape of cancer...

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