Tagged: Genetics

Tumour cells avoid crowds

Densely packed tumour cells produce molecules that help them to migrate and spread, or metastasize, throughout the body. Daniele Gilkes at Johns Hopkins University in Baltimore, Maryland, and her colleagues studied metastatic human sarcoma...

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Notch1 promotes cancer spread

Mutations that activate Notch have been identified in several cancers. Weiland et al. find that Notch1 signaling within endothelial cells (ECs) promotes the invasion of distant organs by tumors. Abnormally high levels of active...

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A bacterial global regulator forms a prion

Prions enter another domain of life Prions are self-propagating protein aggregates, discovered in connection with the fatal transmissible spongiform encephalopathies in mammals. Prions have also been identified in fungi, where they act as protein-based...

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TYK2’s balancing act

Determining the biological consequences of the thousands of genetic variants that contribute to common diseases is challenging. Genetic variants that influence autoimmune diseases have been identified in the gene encoding TYK2 (tyrosine kinase 2),...

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Harvest time for CRISPR-Cas?

The revolutionary gene editing technology CRISPR-Cas is on the verge of widespread application in agriculture, promising easy access to dramatic crop improvements. Companies now licensing the technology face the challenge of regaining the public...

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Mosaic mutations in autism

Spontaneously arising de novo mutations are likely important contributors to the development of autism spectrum disorder (ASD) in affected individuals. Genetic mutation is an ongoing process. Although people inherit deleterious mutations from their parents,...

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Sexual dimorphism in cancer

The incidence of many types of cancer arising in organs with non-reproductive functions is significantly higher in male populations than in female populations, with associated differences in survival. Occupational and/or behavioural factors are well-known...

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