Tagged: Gene Expression

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Cellular Cartography

Over the next decade, researchers will compile a comprehensive and freely available map of the cells of the human body, complete with descriptions about their anatomy and function, according to a global initiative launched...

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Drugging an undruggable target

Transcription factors have long been viewed as “undruggable” targets for therapy: however, this concept may now need some tweaking. Cho et al. found that a small-molecule drug (PT2399) that inhibits the activity of the...

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CRISPRi-Controlled Gene Expression

A team of researchers at the Gladstone Institutes in San Francisco, California, has used a version of CRISPR gene editing known as CRISPR interference (CRISPRi) to reversibly and accurately suppress gene expression in induced pluripotent...

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Rethinking Telomeres

EDITOR’S CHOICE IN GENETICS & GENOMICS The paper J.D. Robin et al., “Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances,” Genes Dev, 28:2464-76, 2014. Telomeres are DNA repeats...

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Epigenetic Changes Can Cause Cancer

Changes in gene methylation alone can trigger cancer, according to a mouse study published today (July 25) in the Journal of Clinical Investigation. Working in mouse stem cells, researchers from Baylor College of Medicine in...

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Mutations Pervade Mitochondrial DNA

Mutations in one or more copies of mitochondrial DNA, known as heteroplasmies, are likely to be much more common in healthy people than previously anticipated. Approximately 90 percent of healthy participants in the 1,000...

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Shushing RNA

Although small interfering RNAs (siRNAs) are largely explored today for their potential in gene therapy, the phenomenon was first described in plants, which employ siRNAs to disable foreign RNA from viral infections. Researchers have...

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