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FUNCTIONAL SUBCLONE PROFILING FOR PREDICTION OF TREATMENT-INDUCED INTRA-TUMOR POPULATION SHIFTS AND DISCOVERY OF RATIONAL DRUG COMBINATIONS IN HUMAN GLIOBLASTOMA

Purpose: Investigation of clonal heterogeneity may be key to understanding mechanisms of therapeutic failure in human cancer. However, little is known on the consequences of therapeutic intervention on the clonal composition of solid tumors....

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Resistance fighters

Evolutionary biologists have begun studying the rise of antibiotic resistance, one of the most urgent problems in public health. Their work suggests that old dogmas about the best way to prevent resistance may be...

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One in Four Americans Has Been Addicted to Painkillers or Is Close to an Addict

Doctors wrote 259 million opioid prescriptions for Americans in 2012, enough to medicate every adult in the country. Drug overdoses are eclipsing car crashes as a leading cause of accidental death for American adults. A poll out today from the Kaiser...

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Tying up a transcription factor

Transcription factors form multiprotein complexes that coordinate gene expression and regulate cellular responses (1). In cancer, aberrantly expressed transcription factors often alter gene expression programs, and although these transcription factors are promising targets for...

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Drug Spurs Digestion

A drug called fexaramine triggers a physiological reaction in mice akin to what happens after the animals eat a big meal: releasing bile acids into the intestines to digest food, according to a study...

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