Tagged: DNA

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LAMP shines a light on Zika virus

Rapid and simple assays to detect infectious agents are key to tracking emerging epidemics. Chotiwan et al. describe a loop-mediated amplification (LAMP) assay that detects Zika virus RNA in human biofluids such as serum...

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Mosaic mutations in autism

Spontaneously arising de novo mutations are likely important contributors to the development of autism spectrum disorder (ASD) in affected individuals. Genetic mutation is an ongoing process. Although people inherit deleterious mutations from their parents,...

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Cancer Sequencing Controls

It is increasingly common practice for researchers to scan DNA sequence data from tumor biopsies of cancer patients—the idea being that the presence of mutations might inform tailored treatments or prognoses. It is not...

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Repurposed Retroviruses

Retroviral sequences in mammalian genomes are the remnants of old viral infections and, for the most part, their expression is suppressed. But a report published today (December 18) in Science suggests that, in B...

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Heritable Histones

After DNA replication and division, cells generally remember which of their genes should be active and which repressed but how? A study in worms published today (September 18) in Science reveals that part of the mechanism...

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Epigenome reprogramming of mice and men

Two new studies have characterized the genome-scale landscapes of DNA methylation in human early embryos. Although the broad principles of how the epigenome is reprogrammed during early embryonic development seem to be conserved from...

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Cancer biomarkers: Written in blood

In 2012, Charles Swanton was forced to confront one of cancer’s dirtiest tricks. When he and his team at the Cancer Research UK London Research Institute sequenced DNA from a handful of kidney tumours,...

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Beneficial Brew

The context Researchers have long reported that green tea drinkers have better health outcomes, but why that is has been unclear. To get to the cellular roots of these observations, Iris Benzie of the...

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