Tagged: disease/medicine

The Celiac Surge

In 2015, gastroenterologist Edwin Liu set to work on a clinical and genetic data set that had been growing for more than 20 years. The data pertained to celiac disease, a lifelong condition involving...

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Should Healthy People Have Their Exomes Sequenced?

For people with no perceivable health issues but who are curious about some potential future ailments, there are now a handful of companies offering whole-genome or exome sequencing services to identify potential disease risks...

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Pathway to Polio Virulence Revealed

Polio is nearly eradicated. Now much of the risk of polio outbreaks comes not from wild poliovirus but from the oral vaccine, which comprises attenuated viruses. These viruses accumulate mutations that allow them to...

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Toward Killing Cancer with Bacteria

A genetically manipulated version of the gastroenteritis-causing bacteria Salmonella typhimurium is a potent destroyer of mouse tumors, according to a report published today (February 8) in Science Translational Medicine. The paper adds to a...

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Oligonucleotide Therapeutics Near Approval

Cold Spring Harbor Laboratory molecular geneticist Adrian Krainer was at a National Institutes of Health workshop in 1999 when he first learned about the crippling neurodegenerative disease spinal muscular atrophy (SMA)—the leading genetic cause...

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Nixing NETs to Prevent Metastasis

Tumor cells undergoing metastasis prompt neutrophils to extrude stringy DNA webs known as neutrophil extracellular traps (NETs) that help the cancer invade other tissues, according to a paper published today (October 19) in Science...

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CRISPR Therapy to Enter Trials

Oncologist You Lu of Sichuan University’s West China Hospital in Chengdu and colleagues will soon begin trialing a new CRISPR-based immunotherapy in 10 patients with non-small cell lung cancer that has metastasized and is...

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Altered Sense of Touch in Autism?

Mice with certain mutations in the touch receptors in their skin are more easily startled by small puffs of air than their wild-type counterparts, according to a study published this week (June 9) in...

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Zooming In on an Antidepressant Target

Researchers at the Vollum Institute in Portland, Oregon, have resolved the crystal structures of the human serotonin transporter (SERT) bound to two different antidepressant drugs. The structures show where the drugs bind, how they...

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Aging Shrinks Chromosomes

In cells undergoing senescence, chromosomes tend to become more compact, according to a report published today (February 5) in Science Advances.This and other chromatin rearrangements noted in the report add to a growing understanding...

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Viral Soldiers

n July 2011, a 43-year-old woman walked out of the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland, after a month of battling a serious bacterial infection. Three weeks later, two more...

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