Tagged: CRISPR

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CRISPR Corrects Duchenne-Causing Mutations

Researchers have been studying the CRISPR-Cas9 gene-editing system as a potential therapeutic tool to modify or delete pathogenic sequences within the human genome. Now, using a more recently discovered system, CRISPR-Cpf1, researchers have demonstrated...

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Rethinking a Cancer Drug Target

A protein thought to be essential for cancer cells may not be so essential after all, according to a study published today (March 24) in eLife. Researchers at Cold Spring Harbor Laboratory (CSHL) in...

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New CRISPR-Cas Enzymes Discovered

Microbes use a number of CRISPR-Cas systems for immunity, but it’s the class 2 system, typically utilizing the nuclease Cas9, that has been adapted for genome editing. A metagenomics search of microbes sampled from...

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Life Science Controversies of 2016

Two ongoing disputes brought The Scientist to the courtroom to listen in on the proceedings this year. The first is a defamation suit that former Wayne State University researcher Fazlul Sarkar brought against anonymous...

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Human CRISPR Trials Could Become Sputnik 2.0

It was the injection heard around the world. On October 28th, a team of scientists at Sichuan University in Chengdu, China, delivered the first cells that had been genetically altered using the revolutionary genome-editing...

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Harvest time for CRISPR-Cas?

The revolutionary gene editing technology CRISPR-Cas is on the verge of widespread application in agriculture, promising easy access to dramatic crop improvements. Companies now licensing the technology face the challenge of regaining the public...

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Targeting the Noncoding Genome with CRISPR

Demonstrating yet another basic research application of CRISPR, two teams have independently reported scaled up CRISPR interference (CRISPRi) and CRISPR/Cas9 noncoding genomic screens. Researchers at MIT and the Broad Institute of MIT and Harvard used...

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CRISPR: No Cutting Required

Taking advantage of a deaminase enzyme that introduces a single nucleotide change to DNA, researchers have created a modified CRISPR/Cas9tool that avoids the generation of a deleterious double-stranded break, minimizes the potential for the...

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CRISPR Therapy to Enter Trials

Oncologist You Lu of Sichuan University’s West China Hospital in Chengdu and colleagues will soon begin trialing a new CRISPR-based immunotherapy in 10 patients with non-small cell lung cancer that has metastasized and is...

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A New CRISPR System for RNA

While the CRISPR/Cas9 genome editing system has been “burning up the charts”, so to speak, with its extraordinary versatility and potential for treating a host of diseases, until now its editing capabilities have been...

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CRISPR views of embryos and cells

Two teams have developed innovative new applications of the popular genome-editing method CRISPR. One of the groups has used it to mark and trace cells in a developing animal. In the method’s first test,...

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How HIV Can Escape an Experimental CRISPR Therapy

CRISPR/Cas9 gene editing has shown remarkable therapeutic potential, including the ability to fightpathogens like HIV. But the same process that inactivates the deadly virus may also enable it to escape the treatment, according to...

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CRISPRi-Controlled Gene Expression

A team of researchers at the Gladstone Institutes in San Francisco, California, has used a version of CRISPR gene editing known as CRISPR interference (CRISPRi) to reversibly and accurately suppress gene expression in induced pluripotent...

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The Heroes of CRISPR

It’s hard to recall a revolution that has swept biology more swiftly than CRISPR. Just 3 years ago, scientists reported that the CRISPR system an adaptive immune system used by microbes to defend themselves...

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Top Technical Advances 2015

Imaging Life-science imaging broke barriers this year, as scientists built upon microscopy approaches to peer ever deeper into living tissues. In October, Purdue University’s Ji-Xin Cheng and colleagues reported they had greatly increased the...

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