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NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans

Abstract Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases produce ROS locally in response to various stimuli, and thereby regulate...

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LAMP shines a light on Zika virus

Rapid and simple assays to detect infectious agents are key to tracking emerging epidemics. Chotiwan et al. describe a loop-mediated amplification (LAMP) assay that detects Zika virus RNA in human biofluids such as serum...

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Reprogramming to resist

One means by which cancer cells evade therapies involves their ability to reprogram to a cell type that no longer depends on the cellular pathway being targeted by the treatments. Hormone deprivation therapies that...

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Receptor methylation controls behavior

D2 dopamine receptors are targeted by antipsychotic agents to regulate behavior. Likhite et al. found putative arginine methylation motifs in some human G protein–coupled receptors (GPCRs), including the D2 dopamine receptor, and in homologs...

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Fragmented communication between immune cells

Immune cells constantly circulate in the body in search of pathogens or tissue damage. Because they move autonomously, immune cell trafficking must be tightly controlled and coordinated by extracellular cues. The main signals that...

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An inhibitor breaks RANK

Osteoclasts are cells that break down bone; however, excessive bone loss leads to conditions such as osteoporosis. When three proteins called RANKL bind to three receptors called RANK on the osteoclasts’ surfaces, the osteoclasts...

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Protein Helps Cells Adapt—or Die

A cellular stress pathway called the unfolded-protein-response (UPR) both activates and degrades death receptor 5 protein (DR5), which can promote or prevent cell suicide, according to a paper published in Science today (July 3). The theory...

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