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A new direction for breast cancer therapy

Triple-negative breast cancer has the worst prognosis of the breast cancer subtypes. Aggressive forms of this cancer show elevated signaling through the transcription factor MYC, but blocking MYC activity remains challenging because of its...

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Junk DNA Helps Suppress Breast Cancer

A piece of noncoding DNA helps prevents cells from turning cancerous, and does so via two mechanisms. The noncoding DNA, which is called GNG12-ASI, acts both directly by regulating the transcription of a cell-replication...

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Decoding Breast Cancer Drug Resistance

Estrogen is so intimately involved in breast cancer that drugs which disrupt the hormone’s actions have become frontline treatments for the disease. These so-called “hormonal therapies” include tamoxifen and fulvestrant, which directly block the...

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Mammography Screening — Polling Results

Recently, we gave readers the opportunity to share their opinions on mammography screening in Clinical Decisions, an interactive feature in which experts discuss a controversial topic and readers vote and post comments. The feature...

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New Anti-Cancer Agent Developed for HER2-Positive Breast Cancer Shows Promise in Pre-Clinical Studies

Clinical Cancer Research, 2011. Doi: 10.1158/1078-0432. CCR-10-2887. Rafal Zielinski, Ilya Lyakhov, Moinuddin Hassan, Monika Kuban, Kimberly Shafer-Weaver, Amir Gandjbakhche, and Jacek Capala. “HER2-Affitoxin: A Potent Therapeutic Agent for the Treatment of HER2-Overexpressing Tumors”. Scientists at the...

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