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Notch1 promotes cancer spread

Mutations that activate Notch have been identified in several cancers. Weiland et al. find that Notch1 signaling within endothelial cells (ECs) promotes the invasion of distant organs by tumors. Abnormally high levels of active...

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In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery

The blood disorder, β-thalassaemia, is considered an attractive target for gene correction. Site-specific triplex formation has been shown to induce DNA repair and thereby catalyse genome editing. Here we report that triplex-forming peptide nucleic...

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Tumor Models Bridge Mouse-Human Gap

Precision medicine is all about the two T’s—targets and treatments—targets that emerge from analyses of patient-specific information, and treatments that hit these targets. Both T’s, however, pose difficulties. All too often, insights and drug...

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Turning Back the Brain’s Clock

The time window for the brain to develop optimal connections based on learning and experience is relatively short-lived, occurring prior to adulthood. But this neuroplasticity can be restarted in the visual cortex of adult...

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Modeling Ebola in Mice

Researchers investigating host responses to Ebola have long faced a significant disadvantage: the virus kills conventional lab mice, but does not produce the hemorrhagic fever or other classical symptoms that occur in humans. The...

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Epigenetic Changes Can Cause Cancer

Changes in gene methylation alone can trigger cancer, according to a mouse study published today (July 25) in the Journal of Clinical Investigation. Working in mouse stem cells, researchers from Baylor College of Medicine in...

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Next Generation: See-through Mice

The technique: Pumping tissue-clearing reagents through an animal’s circulatory system removes lipids and leaves the remaining tissues practically see-through, according to a paper published today (July 31) in Cell. The new method, which builds upon previous...

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