The Israel Molecular Medicine Portal

A composite window into human history

Over the past decade, the ability to recover whole genomes from ancient remains has emerged as a powerful tool for understanding the human past. From a strictly biological perspective, the sequencing of ancient genomes...

The Celiac Surge

In 2015, gastroenterologist Edwin Liu set to work on a clinical and genetic data set that had been growing for more than 20 years. The data pertained to celiac disease, a lifelong condition involving...

Deep Brain Stimulation Without Surgery

Deep brain stimulation can improve debilitating, treatment-resistant brain disorders but involves surgically implanting electrodes that often have to penetrate multiple layers of tissue before reaching their targets. In a mouse study published today (June...

Tracking the Evolution of Non–Small-Cell Lung Cancer

BACKGROUNDAmong patients with non–small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to clinical outcome...

Proteasome Activation by Small Molecules

Highlights •Identification of more than ten small-molecule proteasome activators •Proteasome activators increase degradation of model substrates •P38 MAPK inhibition increases the clearance of toxic α-synuclein aggregates Summary Drugs that increase 26S proteasome activity have...

Cooking Up Cancer?

In 1997, construction workers digging an 8.7-km railway tunnel in Sweden began experiencing unusual symptoms: nausea, dizziness, and numbness in their fingers. Around the same time, people living near the dig site discovered paralyzed...

Roadmaps for building the neonatal brain

In the postnatal mammalian brain, neurons continue to be generated and migrate to their home stations. Often, these neuroblasts travel along pathways defined by the blood vessels or the glial cells that surround and...

Picking Out Patterns

t takes a trained eye to determine whether you’ve succeeded in turning a skin cell into a stem cell, or to distinguish between two related cell populations based on a handful of their surface...

Tumour cells avoid crowds

Densely packed tumour cells produce molecules that help them to migrate and spread, or metastasize, throughout the body. Daniele Gilkes at Johns Hopkins University in Baltimore, Maryland, and her colleagues studied metastatic human sarcoma...

Blood Stem Cells Grown in the Lab

Two teams of scientists have generated blood stem cells by reprogramming either human or mouse cells. In both cases, these hematopoietic stem cells successfully produced blood cells when implanted into mice. “This is important...