Author: Portal Content Manager

CHILD ARCHIVE

Monitoring inflammation from within

Inflammation in the gut, whether caused by infection or autoimmunity, is challenging to detect, monitor, and treat. Riglar et al. engineered a strain of Escherichia coli obtained from the gut of a mouse to...

CHILD ARCHIVE

Exercise and the Hallmarks of Cancer

A wealth of evidence supports an association between regular physical activity (PA) and decreased risk for cancer and cancer mortality. This is clearly an important issue given the growing worldwide incidence of both cancer...

CHILD ARCHIVE CHILD ARCHIVE

A composite window into human history

Over the past decade, the ability to recover whole genomes from ancient remains has emerged as a powerful tool for understanding the human past. From a strictly biological perspective, the sequencing of ancient genomes...

CHILD ARCHIVE

The Celiac Surge

In 2015, gastroenterologist Edwin Liu set to work on a clinical and genetic data set that had been growing for more than 20 years. The data pertained to celiac disease, a lifelong condition involving...

CHILD ARCHIVE
CHILD ARCHIVE CHILD ARCHIVE
CHILD ARCHIVE

Deep Brain Stimulation Without Surgery

Deep brain stimulation can improve debilitating, treatment-resistant brain disorders but involves surgically implanting electrodes that often have to penetrate multiple layers of tissue before reaching their targets. In a mouse study published today (June...

CHILD ARCHIVE
CHILD ARCHIVE CHILD ARCHIVE
CHILD ARCHIVE

Tracking the Evolution of Non–Small-Cell Lung Cancer

BACKGROUNDAmong patients with non–small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to clinical outcome...

CHILD ARCHIVE
CHILD ARCHIVE

Proteasome Activation by Small Molecules

Highlights •Identification of more than ten small-molecule proteasome activators •Proteasome activators increase degradation of model substrates •P38 MAPK inhibition increases the clearance of toxic α-synuclein aggregates Summary Drugs that increase 26S proteasome activity have...

CHILD ARCHIVE

Cooking Up Cancer?

In 1997, construction workers digging an 8.7-km railway tunnel in Sweden began experiencing unusual symptoms: nausea, dizziness, and numbness in their fingers. Around the same time, people living near the dig site discovered paralyzed...

CHILD ARCHIVE CHILD ARCHIVE

Roadmaps for building the neonatal brain

In the postnatal mammalian brain, neurons continue to be generated and migrate to their home stations. Often, these neuroblasts travel along pathways defined by the blood vessels or the glial cells that surround and...

CHILD ARCHIVE CHILD ARCHIVE

Picking Out Patterns

t takes a trained eye to determine whether you’ve succeeded in turning a skin cell into a stem cell, or to distinguish between two related cell populations based on a handful of their surface...

CHILD ARCHIVE CHILD ARCHIVE
CHILD ARCHIVE

Tumour cells avoid crowds

Densely packed tumour cells produce molecules that help them to migrate and spread, or metastasize, throughout the body. Daniele Gilkes at Johns Hopkins University in Baltimore, Maryland, and her colleagues studied metastatic human sarcoma...

CHILD ARCHIVE
CHILD ARCHIVE