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Precision medicine using microbiota

Accumulating evidence indicates that dysregulation of microbiota-host interactions associates with various diseases, including inflammatory bowel diseases (IBDs), colorectal cancer, diabetes, and liver cirrhosis (1). Recently, research has generated paradigm shifts in concepts about the...

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Ribosomes ignore the stop sign

Aminoglycoside antibiotics bind to bacterial ribosomes and inhibit protein synthesis. Eukaryotic ribosomes, in contrast, are not strongly inhibited by these molecules but show errors such as inaccurate translation and read-through of stop codons. Prokhorova...

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Cytoplasmic transfer to tumor cells

Macrophages are innate immune cells that, when recruited to tumors, can promote tumor progression. Macrophage activity and phenotype can be influenced by molecules secreted by tumor cells. To monitor macrophage behavior, Roh-Johnson et al....

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Fountain of youth? Dietary supplement may prevent and reverse severe damage to aging brain, research suggests

A dietary supplement containing a blend of thirty vitamins and minerals–all natural ingredients widely available in health food stores–has shown remarkable anti-aging properties that can prevent and even reverse massive brain cell loss, according...

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miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

Bone-resorbing osteoclasts significantly contribute to osteoporosis and bone metastases of cancer1, 2, 3. MicroRNAs play important roles in physiology and disease4, 5, and present tremendous therapeutic potential6. Nonetheless, how microRNAs regulate skeletal biology is underexplored. Here we...

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