Category: Neuroscience

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Deep Brain Stimulation Without Surgery

Deep brain stimulation can improve debilitating, treatment-resistant brain disorders but involves surgically implanting electrodes that often have to penetrate multiple layers of tissue before reaching their targets. In a mouse study published today (June...

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Roadmaps for building the neonatal brain

In the postnatal mammalian brain, neurons continue to be generated and migrate to their home stations. Often, these neuroblasts travel along pathways defined by the blood vessels or the glial cells that surround and...

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Talking sensibly about depression

Summary points Depression is the leading mental health—related cause of the global burden of disease and is the focus of World Health Day 2017. Despite robust evidence of the effectiveness of interventions ranging from...

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Parkinson disease

Parkinson disease is the second-most common neurodegenerative disorder that affects 2–3% of the population ≥65 years of age. Neuronal loss in the substantia nigra, which causes striatal dopamine deficiency, and intracellular inclusions containing aggregates...

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Why pain and stress lead to depression

Chronic stress or pain is associated with the development of depression. Descalzi et al. examined gene expression changes in the brain in mouse models of nerve injury– or chronic stress–induced depression. They found some...

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Canine Models for Alzheimer’s

It’s no secret that fewer than 10 percent of investigational drugs achieve regulatory approval and reach the marketplace. But the chances of success for drugs developed to treat Alzheimer’s disease are even more grim....

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Relief for retinal neurons under pressure

Advancing age predisposes us to a number of neurodegenerative diseases, yet the underlying mechanisms are poorly understood. With some 70 million individuals affected, glaucoma is the world’s leading cause of irreversible blindness. Glaucoma is...

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