Category: Immunology

Monitoring inflammation from within

Inflammation in the gut, whether caused by infection or autoimmunity, is challenging to detect, monitor, and treat. Riglar et al. engineered a strain of Escherichia coli obtained from the gut of a mouse to...

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The Celiac Surge

In 2015, gastroenterologist Edwin Liu set to work on a clinical and genetic data set that had been growing for more than 20 years. The data pertained to celiac disease, a lifelong condition involving...

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Immune sensor maintains gut microbiome

Emerging evidence indicates that the immune system can influence microbiome composition. Chen et al. now report that patients with active ulcerative colitis have low expression of NLRP12, which is best known for its role...

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Pathway to Polio Virulence Revealed

Polio is nearly eradicated. Now much of the risk of polio outbreaks comes not from wild poliovirus but from the oral vaccine, which comprises attenuated viruses. These viruses accumulate mutations that allow them to...

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Developing an HIV vaccine

In 2015, 17 million HIV-infected individuals worldwide were on antiretroviral drug therapies, which are remarkably effective in suppressing the virus. Yet, 6000 people a day became newly infected, making the quest for an effective...

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Tasmanian Devil Cancer Immunotherapy

Scientists working to slow the spread of a deadly facial cancer through populations of the Tasmania’s iconic marsupial Sarcophilus harrisii, or the Tasmanian devil, have announced progress by injecting live cancer cells into individuals...

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The double edge of cancer immunotherapy

Immunotherapies have shown unprecedented efficacy in the treatment of several cancers, including melanoma and lymphoma, and they are now in clinical trials for many others. This type of treatment can differ in form, ranging...

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Anti-CD22 CAR Therapy Leads to ALL Remissions

In a first-in-human trial of an anti-CD22 chimeric antigen receptor T-cell therapy in children and young adults with relapsed and refractory acute lymphocytic leukemia, researchers found that the immunotherapeutic approach was not only feasible...

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