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Initiating lung cancer

Cigarette smoke contributes to epigenetic and genetic changes in lung cancer. But whether and how these alterations interact in lung cancer initiation has remained unclear. Vaz et al. showed that in immortalized lung epithelial...

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A Broad-Spectrum Inhibitor of CRISPR-Cas9

Highlights •Phage-encoded anti-CRISPRs (Acrs) inhibit CRISPR-Cas9 through unique mechanisms •AcrIIC1 controls genome editing by diverse Cas9 orthologs •AcrIIC1 binding disables Cas9’s nucleases without impacting DNA binding •AcrIIC3 promotes dimerization of Cas9 and prevents DNA...

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LAMP shines a light on Zika virus

Rapid and simple assays to detect infectious agents are key to tracking emerging epidemics. Chotiwan et al. describe a loop-mediated amplification (LAMP) assay that detects Zika virus RNA in human biofluids such as serum...

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Initiating an antitumor attack

Cancer is notorious for relapsing after treatment. Such relapses are driven by tumor-initiating cells, a type of stem cell that gives rise to tumors. Damelin et al. determined that a protein called PTK7 is...

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Cellular Cartography

Over the next decade, researchers will compile a comprehensive and freely available map of the cells of the human body, complete with descriptions about their anatomy and function, according to a global initiative launched...

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In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery

The blood disorder, β-thalassaemia, is considered an attractive target for gene correction. Site-specific triplex formation has been shown to induce DNA repair and thereby catalyse genome editing. Here we report that triplex-forming peptide nucleic...

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From Stem Cell to Oocyte In a Dish

Scientists have for this first time reprogrammed murine embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into fully functional oocytes in the laboratory. The paper describing the technique, published today (October 17)...

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