Category: Genetics

A composite window into human history

Over the past decade, the ability to recover whole genomes from ancient remains has emerged as a powerful tool for understanding the human past. From a strictly biological perspective, the sequencing of ancient genomes...

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Sickle Cell Disease

Sickle cell disease is caused by an alteration in a single DNA base, but its clinical manifestations are influenced by other genes and behavioral and environmental factors. Recent findings may indicate an acceleration in...

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CRISPR Corrects Duchenne-Causing Mutations

Researchers have been studying the CRISPR-Cas9 gene-editing system as a potential therapeutic tool to modify or delete pathogenic sequences within the human genome. Now, using a more recently discovered system, CRISPR-Cpf1, researchers have demonstrated...

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Should Healthy People Have Their Exomes Sequenced?

For people with no perceivable health issues but who are curious about some potential future ailments, there are now a handful of companies offering whole-genome or exome sequencing services to identify potential disease risks...

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Notch1 promotes cancer spread

Mutations that activate Notch have been identified in several cancers. Weiland et al. find that Notch1 signaling within endothelial cells (ECs) promotes the invasion of distant organs by tumors. Abnormally high levels of active...

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Non-Chromosomal DNA Drives Tumor Evolution

Genetically, tumors are a mess. Individual tumor cells have a unique spectrum of mutations, and this heterogeneity is known to drive tumor evolution and resistance to cancer treatments. Now, in a study published today...

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A bacterial global regulator forms a prion

Prions enter another domain of life Prions are self-propagating protein aggregates, discovered in connection with the fatal transmissible spongiform encephalopathies in mammals. Prions have also been identified in fungi, where they act as protein-based...

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