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Tangled Up in DNA: New Molecule Has Potential to Help Treat Genetic Diseases and HIV

Nature Chemistry, 2011; 3 (11): 875;  DOI: 10.1038/nchem.1151 Garen G. Holman, Maha Zewail-Foote, Amy Rhoden Smith, Kenneth A. Johnson, Brent L. Iverson. “A sequence-specific threading tetra-intercalator with an extremely slow dissociation rate constant”. Chemists...

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Unmasking a tumor tag-team

Leukemia advance online publication, 25 November 2011 (doi:  10.1038/leu.2011.328). Oki, T.,Kitaura, J.,Watanabe-Okochi, N.,Nishimura, K.,Maehara, A.,Uchida, T.,Komeno, Y.,Nakahara, F.,Harada, Y.,Sonoki, T.,Harada, H.& Kitamura, T. “Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell...

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Israeli study: New synthetic molecules treat autoimmune disease in mice

Nature Medicine 18,143–147 (2012). Doi: 10.1038/nm.2582 Netta Sela-Passwell, Raghavendra Kikkeri, Orly Dym, Haim Rozenberg, Raanan Margalit, Rina Arad-Yellin, Miriam Eisenstein, Ori Brenner, Tsipi Shoham, Tamar Danon, Abraham Shanzer & Irit Sagi. “Antibodies targeting the...

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Researchers designed a new small protein – a functional model of the native Extracellular Matrix which could lead to advances in Regenerative Medicine

Angewandte Chemie International Edition, Volume 51, Issue 2, pages 428–431, January  2012; DOI: 10.1002/anie.201104647 Angelo Bella, Santanu Ray, Michael Shaw and Maxim G. Ryadnov. “Arbitrary Self-Assembly of Peptide Extracellular Microscopic Matrices”. NPL scientists have...

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New study: Targeted Blocking of Cell Death Prevents Fatal Condition Septic Shock

Immunity, 2011; 35 (6): 908 DOI: 10.1016/j.immuni.2011.09.020 Linde Duprez, Nozomi Takahashi, Filip Van Hauwermeiren, Benjamin Vandendriessche, Vera Goossens, Tom Vanden Berghe, Wim Declercq, Claude Libert, Anje Cauwels and Peter Vandenabeele. “RIP Kinase-Dependent Necrosis Drives Lethal Systemic...

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New Hope for Diseases of Protein Folding Such as Alzheimer’s, Parkinson’s Diseases, ALS, Cancer and Diabetes

Nature Chemical Biology, 2011; DOI: 10.1038/nchembio.763 Barbara Calamini, Maria Catarina Silva, Franck Madoux, Darren M Hutt, Shilpi Khanna, Monica A Chalfant, S Adrian Saldanha, Peter Hodder, Bradley D Tait, Dan Garza, William E Balch...

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