Category: Drug Research

PARP Inhibitors for Cancer Therapy

Summary Rucaparib is an inhibitor of nuclear poly (ADP-ribose) polymerases (inhibition of PARP-1 > PARP-2 > PARP-3), following a similar drug, Olaparib. It disrupts DNA repair and replication pathways (and possibly transcription), leading to...

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Easier cure for resistant TB

A new treatment strategy has had astonishing success against extensively drug-resistant tuberculosis (XDR TB), which kills more than 70% of patients. XDR and other drug-resistant forms of TB are burgeoning among people with HIV,...

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Chemoprevention of Recurrent Colorectal Neoplasia

Evidence suggests that, in people with previous colorectal neoplasia, aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) lower risk for metachronous neoplasia (i.e., occurring after resection of initial neoplasia). In this network meta-analysis of 14 randomized...

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Superbug Gene Found on Pig Farm

Modern agriculture relies on antibiotics to shield livestock from disease, but widespread over-use of antibiotics has raised concerns over creating highly resistant “superbugs.” Researchers announced this week (December 5) that bacteria carrying a rare,...

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Cannabinoid receptor structure revealed

Cannabinoid receptor 1 (CB1) represents a promising therapeutic target for a wide range of disorders. However, the molecular details that define the binding modes of both endogenous and pharmac”zs²&ological ligands have remained poorly understood....

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Blocking metastasis

Neutrophil extracellular traps (NETs), made of processed chromatin bound to cytotoxic enzymes, are released by neutrophils into the extracellular space to control microbial infections. However, NETs have also been implicated in cancer metastasis. Here,...

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Replacing factor VIII replacement?

Hemophilia A is a bleeding disorder caused by a deficiency of factor VIII, a protein essential for blood clotting. Injection of recombinant or plasma-derived factor VIII is an effective prophylactic treatment. Factor replacement therapy...

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Resistance fighters

Evolutionary biologists have begun studying the rise of antibiotic resistance, one of the most urgent problems in public health. Their work suggests that old dogmas about the best way to prevent resistance may be...

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Viral Soldiers

n July 2011, a 43-year-old woman walked out of the National Institutes of Health (NIH) Clinical Center in Bethesda, Maryland, after a month of battling a serious bacterial infection. Three weeks later, two more...

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