Category: Cancer

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A new cancer ecosystem

Cancer is increasingly being viewed as an ecosystem, a community in which tumor cells cooperate with other tumor cells and host cells in their microenvironment. As conditions change, the ecosystem evolves and adapts to...

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Tasmanian Devil Cancer Immunotherapy

Scientists working to slow the spread of a deadly facial cancer through populations of the Tasmania’s iconic marsupial Sarcophilus harrisii, or the Tasmanian devil, have announced progress by injecting live cancer cells into individuals...

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Exploiting cancer metabolism

Cancer-specific cell surface proteins can be targeted for the delivery of therapeutic agents. However, specific proteins may not always be expressed by a tumor. Wang et al. overcome this challenge by designing sugars to...

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The double edge of cancer immunotherapy

Immunotherapies have shown unprecedented efficacy in the treatment of several cancers, including melanoma and lymphoma, and they are now in clinical trials for many others. This type of treatment can differ in form, ranging...

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Anti-CD22 CAR Therapy Leads to ALL Remissions

In a first-in-human trial of an anti-CD22 chimeric antigen receptor T-cell therapy in children and young adults with relapsed and refractory acute lymphocytic leukemia, researchers found that the immunotherapeutic approach was not only feasible...

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George Klein (1925–2016)

George Klein, with his wife, Eva, discovered foundational phenomena in cancer research. He showed that normal cells carry genes, now known as tumour suppressors, that prevent cancer. He also worked out how the immune...

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How Much Longer Will We Put Up With $100,000 Cancer Drugs?

The spiraling cost of new drugs mandates a fundamentally different approach to keep lifesaving therapies affordable for cancer patients. We call here for the formation of new relationships between academic drug discovery centers and commercial...

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Non-Chromosomal DNA Drives Tumor Evolution

Genetically, tumors are a mess. Individual tumor cells have a unique spectrum of mutations, and this heterogeneity is known to drive tumor evolution and resistance to cancer treatments. Now, in a study published today...

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Toward Killing Cancer with Bacteria

A genetically manipulated version of the gastroenteritis-causing bacteria Salmonella typhimurium is a potent destroyer of mouse tumors, according to a report published today (February 8) in Science Translational Medicine. The paper adds to a...

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