Category: Cancer

Exercise and the Hallmarks of Cancer

A wealth of evidence supports an association between regular physical activity (PA) and decreased risk for cancer and cancer mortality. This is clearly an important issue given the growing worldwide incidence of both cancer...

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Tracking the Evolution of Non–Small-Cell Lung Cancer

BACKGROUNDAmong patients with non–small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to clinical outcome...

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Cooking Up Cancer?

In 1997, construction workers digging an 8.7-km railway tunnel in Sweden began experiencing unusual symptoms: nausea, dizziness, and numbness in their fingers. Around the same time, people living near the dig site discovered paralyzed...

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Tumour cells avoid crowds

Densely packed tumour cells produce molecules that help them to migrate and spread, or metastasize, throughout the body. Daniele Gilkes at Johns Hopkins University in Baltimore, Maryland, and her colleagues studied metastatic human sarcoma...

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Gut Organoid Transplants Produce Colorectal Cancer in Mice

In recent years, scientists have developed organoids, stem-cell-derived organs-in-a-dish, for a number of tissues, including kidneys, guts, and brains. While these mini-organs provide a useful tool to study both development and disease, many researchers...

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Countering chemo’s effects on fertility

Conventional chemotherapy with DNA-damaging agents has helped countless cancer patients become cancer survivors. This successful outcome is sometimes accompanied by long-term side effects, however. In young female patients, for example, the alkylating agent cyclophosphamide...

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PARP Inhibitors for Cancer Therapy

Summary Rucaparib is an inhibitor of nuclear poly (ADP-ribose) polymerases (inhibition of PARP-1 > PARP-2 > PARP-3), following a similar drug, Olaparib. It disrupts DNA repair and replication pathways (and possibly transcription), leading to...

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Rethinking a Cancer Drug Target

A protein thought to be essential for cancer cells may not be so essential after all, according to a study published today (March 24) in eLife. Researchers at Cold Spring Harbor Laboratory (CSHL) in...

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Notch1 promotes cancer spread

Mutations that activate Notch have been identified in several cancers. Weiland et al. find that Notch1 signaling within endothelial cells (ECs) promotes the invasion of distant organs by tumors. Abnormally high levels of active...

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