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Genetics of pancreatitis

Nature Genetics 44, 1349–1354 (2012) David Whitcomb et al. “Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis” David Whitcomb, Bernie Devlin and colleagues report the results of a genome-wide...

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Tangled Up in DNA: New Molecule Has Potential to Help Treat Genetic Diseases and HIV

Nature Chemistry, 2011; 3 (11): 875;  DOI: 10.1038/nchem.1151 Garen G. Holman, Maha Zewail-Foote, Amy Rhoden Smith, Kenneth A. Johnson, Brent L. Iverson. “A sequence-specific threading tetra-intercalator with an extremely slow dissociation rate constant”. Chemists...

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Unmasking a tumor tag-team

Leukemia advance online publication, 25 November 2011 (doi:  10.1038/leu.2011.328). Oki, T.,Kitaura, J.,Watanabe-Okochi, N.,Nishimura, K.,Maehara, A.,Uchida, T.,Komeno, Y.,Nakahara, F.,Harada, Y.,Sonoki, T.,Harada, H.& Kitamura, T. “Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell...

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