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  • Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

    The blood–brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in Alzheimer’s disease (AD) before dementia, neurodegeneration and/or brain atrophy...

    Neuroscience

  • Genomes rewrite cholera’s global story

    Summary By sequencing and comparing hundreds of bacterial genomes, researchers have shown that all of the explosive epidemics of cholera in Africa and the Americas in the past half-century arose after the arrival of...

    Genetics / Home Page

  • Metabolic regulation of genome stability

    Cells respond to metabolic fluctuations by adjusting the speed of DNA replication as a safeguard for genome stability. Somyajit et al. elucidate the cellular mechanisms that align replication fork dynamics with metabolic pathways (see...

    Genetics

  • Migrating into the Tumor: a Roadmap for T Cells

    Tumors can be divided into ‘hot’ (T cell inflamed) or ‘cold’ (T cell noninflamed) according to the presence of immune cells. In this review, we discuss variables that influence T cell migration into the...

    Cancer

  • Getting Drugs Past the Blood-Brain Barrier

    On a fall day in 2015 at Sunnybrook hospital in Toronto, a dozen people huddled in a small room peering at a computer screen. They were watching brain scans of a woman named Bonny...

    Drug Research / Neuroscience

  • Equivocal Findings of Alzheimer’s Trial Using Young Blood

    A small clinical trial testing the safety of administering young people’s blood plasma to treat Alzheimer’s disease has found that the approach may slightly improve patients’ cognitive function, according to researchers at Stanford University....

    Neuroscience

  • RNA Interference Drug Excels in Clinical Trials to Treat Rare Disorder

    Alnylam Pharmaceuticals is reporting positive results from a clinical trial using patisiran—an RNA interference (RNAi) drug—to treat patients suffering from hereditary amyloidosis with polyneuropathy, a life-threatening genetic disorder. Alnylam has announced it plans to...

    Genetics

  • Gut microbes shape response to cancer immunotherapy

    This week, two studies offer a raft of evidence from cancer patients suggesting that the gut microbiome—the community of bacteria, viruses, and other bugs living in our digestive tracts—helps determine whether tumors shrink when...

    Cancer

  • Soaking up tumor suppression

    MicroRNAs (miRNAs) regulate gene expression by inducing mRNA decay. But miRNAs can be regulated through other RNAs and DNA that bind and sequester them without inducing any mRNA decay; these are known as miRNA...

    Cancer

  • Alzheimer’s May Start in Body, Not Just Brain

    Alzheimer’s disease may move, cancer like, from place to place in the body, lodging in the brain after originating in peripheral tissues. Just how much Alzheimer’s begins in the body as opposed to the...

    Neuroscience