- In early 2012, Emmanuelle Charpentier, a little-known French microbiologist who would soon meet worldwide fame, contacted her old friend Rodger Novak to ...
- A new treatment strategy has had astonishing success against extensively drug-resistant tuberculosis (XDR TB), which kills more than 70% of patients. XDR ...
- Advancing age predisposes us to a number of neurodegenerative diseases, yet the underlying mechanisms are poorly understood. With some 70 million individuals ...
- Vitamin B3 protects mice from glaucoma Glaucoma is the most common cause of age-related blindness in the United States. There is currently no ...
- When is a mutation a true genetic variant? Large-scale sequencing studies have set out to determine the low-frequency pathogenic genetic variants in individuals ...
- Type I interferons have been shown to play a major role in anti-cancer immunity. In this issue of Cancer Cell, Katlinski et al. ...
- George Klein, with his wife, Eva, discovered foundational phenomena in cancer research. He showed that normal cells carry genes, now known as ...
- Over the past few decades, the number of deaths from cardiovascular disease has declined substantially in developed countries. Statins, drugs that lower ...
- With both small molecules and biologics succeeding in trials and in the clinic, the scope of drug discovery in cancer is changing. ...
Paul Workman et al.
The spiraling cost of new drugs mandates a fundamentally different approach to keep lifesaving therapies affordable for cancer patients. We call here for the formation of new relationships between academic drug discovery centers and commercial...
L. Bryan Ray
It is not easy being a cancer cell, so such cells may need help from factors other than oncogenes that contribute to the cancer cell phenotype. Bublik et al. identify such a factor in...
With over 10 million active cases in 2015 and close to 2 million deaths, tuberculosis (TB) remains a leading cause of death worldwide. Moreover, the rampant spread of drug-resistant TB has rendered many common...
Naoya Sakamoto et al.
Feixiong Cheng, Joseph Loscalzo